反应详情

To a solution of 1.0 g (0.0042 mole) of (4-fluoro3-phenoxyphenyl)methyl chloride in 5 mL of dry toluene was added 0.15 g (0.0063 mole) of sodium hydride. Dropwise a solution of 0.98 g (0.0047 mole) of 2-(4-ethoxyphenyl)-2-methyl-2-silapropanol in 5 mL of dry toluene was added to the reaction mixture. The reaction mixture was stirred at room temperature for one hour and then was heated at reflux for three hours. Aqueous 10% hydrochloric acid was added to the reaction mixture which was then extracted twice with diethyl ether. The combined extracts were dried, filtered through silica gel, and the solvent was evaporated under reduced pressure, leaving a residue. This residue was subjected to Kugelrohr distillation to remove remaining starting materials. The residue from this distillation was separated into two major fractions using a Chromatotron (eluant=ethyl acetate/ hexane (2:98). The smaller fraction, weighing 0.19 g, was determined to be (4-fluoro-3-phenoxyphenyl)methyl 2-(4-ethoxyphenyl)-2-methyl-2-silapropyl ether from its nmr spectrum.

1. temperaturewas heated
2. temperatureat reflux for three hours
3. extractionwas then extracted twice with diethyl ether
4. customThe combined extracts were dried
5. filtrationfiltered through silica gel
6. customthe solvent was evaporated under reduced pressure
7. customleaving a residue
8. distillationThis residue was subjected to Kugelrohr distillation
9. customto remove
10. distillationThe residue from this distillation
11. customwas separated into two major fractions