反应详情

15 ml of 2N sodium hydroxide solution are added to a solution of 1.50 g (0.004 mol) of ethyl N-[2-(4-acetamidobutyryl)-5-chlorohydrocinnamoyl]glycinate in 15 ml of tetrahydrofuran and the mixture is stirred at room temperature for 1 hour. After acidification with 17 ml of 2N hydrochloric acid, the mixture is extracted with ethyl acetate/water, dried with magnesium sulfate and the solvent is distilled in a vacuum. Recrystallization from ethyl acetate/ether yields N-[2-(4-acetamidobutyryl)-5-chlorohydrocinnamoyl]glycine as white crystals with melting point 88°-89°.

1. extractionAfter acidification with 17 ml of 2N hydrochloric acid, the mixture is extracted with ethyl acetate/water
2. dry with materialdried with magnesium sulfate
3. distillationthe solvent is distilled in a vacuum
4. customRecrystallization from ethyl acetate/ether