Acetonitrile → HCID 1787923, compound

HRID 1639416Notes

Reaction equation

HRID 1639416 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].C(#N)C.[C:10]1([CH2:16][CH2:17][C:18](Cl)=[O:19])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([CH2:16][CH2:17][C:18]([NH:3][NH:2][C:1]([O:5][CH3:6])=[O:4])=[O:19])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 64801Benzenepropanoyl chlorideHCID 80519Methyl carbazate

Product 1

HCID 1787923HCID 1787923, compoundYield 80.7%

Procedure

To a solution of 18 g. (0.2 moles) of methyl carbazate and 100 ml. of acetonitrile 33.7 g (0.2 moles) of β-phenylpropionyl chloride are added dropwise. The reaction mixture is heated to boiling for 15 hours, clarified and cooled. The crystals are filtered off. Thus 36.85 g of the desired compound are obtained, yield 80.7% m.p.: 118° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperaturecooled
  3. filtrationThe crystals are filtered off

Sources & evidence

ORD record
ord-fa1540cf39b94328a79b5ec674c486ca
Source dataset
uspto-grants-1989_11
Patent number
US04883907

Reaction notes

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