3-Chloropropionyl chloride → HCID 19839192, compound

HRID 1639419Notes

Reaction equation

HRID 1639419 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].[Cl:7][CH2:8][CH2:9][C:10](Cl)=[O:11]>C(#N)C>[Cl:7][CH2:8][CH2:9][C:10]([NH:3][NH:2][C:1]([O:5][CH3:6])=[O:4])=[O:11]

Participants

4

Reactant 2

HCID 693643-Chloropropionyl chlorideHCID 80519Methyl carbazate

Product 1

HCID 19839192HCID 19839192, compoundYield 78.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 45 g. (0.5 moles) of methyl carbazate in 375 ml. of acetonitrile 63.5 g. (0.5 moles) of 3-chloro-propionyl chloride are added dropwise. The reaction mixture is heated to boiling for 16 hours, clarified and cooled. The precipitated crystals are filtered. Thus 70.5 g. of the desired compound are obtained in the form of white crystals. Yield: 78.3%. M.p.: 129° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperaturecooled
  3. filtrationThe precipitated crystals are filtered

Sources & evidence

ORD record
ord-94523d16dc3647ada9bc14ca9c546091
Source dataset
uspto-grants-1989_11
Patent number
US04883907

Reaction notes

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