Hydrazine hydrate (1:1) → HCID 178434284, compound

HRID 16395Notes

Reaction equation

HRID 16395 reaction equation
[F:1][C:2]1[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[C:7]([CH3:14])=[N:8][NH:9]2.O.NN>C(O)C.[Pd]>[F:1][C:2]1[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:6]=1[C:7]([CH3:14])=[N:8][NH:9]2

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178434285HCID 178434285, compound

Product 1

HCID 178434284HCID 178434284, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

75 mg (0.26 mmol) of 4-(2-fluoro-4-nitrophenoxy)-3-methyl-1H-indazole (from example II) are dissolved in 3 ml of ethanol, and 261 mg (5.22 mmol) of hydrazine hydrate and 10 mg of 10% palladium on activated carbon are added. The mixture is heated at 80° C. for two hours and then filtered through kieselguhr. The filtrate is concentrated under reduced pressure.

Workup

  1. filtrationfiltered through kieselguhr
  2. concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-5894a7d3c90d43aba0f306a7accb830f
Source dataset
uspto-grants-2010_06
Patent number
US07737153B2

Reaction notes

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