反应详情

7-Bromo-5H-pyrrolo[2,3-b]pyrazine (4) is prepared by dissolving 5H-pyrrolo[2,3-b]pyrazine (3) in chloroform and slowly adding Br2 in carbon tetrachloride at 0° C. After stirring for 1-2 hours, the reaction may be quenched in aqueous hydrochloric acid. Isolation by conventional means (e.g. extraction and silica gel chromatography) provides compound 4.

1. custom7-Bromo-5H-pyrrolo[2,3-b]pyrazine (4) is prepared
2. customthe reaction
3. custommay be quenched in aqueous hydrochloric acid
4. extractionIsolation by conventional means (e.g. extraction and silica gel chromatography)