HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 3-Bromo-4,7-diazaindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5H-Pyrrolo[2,3-b]pyrazine | HCID 5370803 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-Bromo-4,7-diazaindole | HCID 12207193 | — |
Reaction Steps
7-Bromo-5H-pyrrolo[2,3-b]pyrazine (4) is prepared by dissolving 5H-pyrrolo[2,3-b]pyrazine (3) in chloroform and slowly adding Br2 in carbon tetrachloride at 0° C. After stirring for 1-2 hours, the reaction may be quenched in aqueous hydrochloric acid. Isolation by conventional means (e.g. extraction and silica gel chromatography) provides compound 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08110576B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-79048935ae504ba0b321b0211ee5ad71 |
| Source note | uspto-grants-2012_02 |