反应详情

温度

80 °C

Add 5-methyl-2H-pyrazol-3-ylamine (217 mg, 2.17 mmol), nonane-2,4-dione (339 mg, 2.39 mmol) and piperidine (1 drop) to ethanol (10 mL) and heat at 80° C. overnight. Cool to room temperature and concentrate to dryness. Purify by silica gel column chromatography (0-20% ethyl acetate in hexane) to obtain a mixture of two isomers (2 g).

1. temperatureCool to room temperature
2. concentrationconcentrate to dryness
3. customPurify by silica gel column chromatography (0-20% ethyl acetate in hexane)
4. customto obtain
5. additiona mixture of two isomers (2 g)