反应详情

A mixture of methyl 2-iodo-3-nitrobenzoate (77.0 g, 251 mmol) and a catalytic amount of Raney nickel in ethyl acetate (100 mL) was stirred under hydrogen atmosphere at room temperature for 2 days, and filtered through celite. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=1/10) to give the title compound (60.0 g, yield 86%).

1. filtrationfiltered through celite
2. customThe solvent was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane=1/10)