HCID 54046874, compound → HCID 15430886, compound

HRID 1639841Notes

Reaction equation

HRID 1639841 reaction equation
[CH2:1]([S:8][C:9]1[C:18]([N+:19]([O-])=O)=[CH:17][CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].C(OCC)(=O)C>[NH2:19][C:18]1[C:9]([S:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 54046874HCID 54046874, compound

Product 1

HCID 15430886HCID 15430886, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Under hydrogen atmosphere, a mixture of methyl 2-(benzylthio)-3-nitrobenzoate (28.5 g, 94.0 mmol) and a catalytic amount of Raney nickel in ethyl acetate (500 mL) was stirred at room temperature for 12 hr, and filtered through celite. The solvent was evaporated under reduced pressure to give the title compound (25.7 g, yield 96%).

Workup

  1. filtrationfiltered through celite
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0efee4fb46d54427b3e3d33bad98b510
Source dataset
uspto-grants-2012_02
Patent number
US08110585B2

Reaction notes

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