1h-Indazole,5-(2-fluoro-4-nitrophenoxy)- → 5-(4-Amino-2-fluorophenoxy)-1H-indazole

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Reaction Steps

1.96 g (7.17 mmol) of 5-(2-fluoro-4-nitrophenoxy)-1H-indazole (from example IX) are dissolved in 50 ml of ethanol. 0.16 g (0.71 mmol) of platinum(IV) oxide are added, and the mixture is hydrogenated at room temperature under atmospheric pressure for two hours. For work-up, the mixture is filtered off with suction through kieselguhr, the filtercake is washed with ethanol and the filtrate is concentrated.

Provenance & Evidence