反应详情

温度

125 °C

A solution of 0.47 g (2.0 mmol) of N,N-diethyl-(2-hydroxy-6-methoxyphenyl)acetamide in 5.0 mL of toluene was added with 0.92 mL (1.36 g, 12 mmol) of trifluoroacetic acid and heated and stirred on a 125° C. oil bath of for 71 minutes. The mixture was cooled under room temperature, and after that added with 24 mL of 0.5 N aqueous sodium hydroxide, while being stirred, and then transferred into a separatory funnel and settled. The aqueous layer was separated and discarded and after the organic layer was washed with 5 mL of water twice, the solvent was evaporated to obtain 0.27 g of the title compound.

1. temperatureheated
2. temperatureThe mixture was cooled under room temperature
3. stirringwhile being stirred
4. customtransferred into a separatory funnel
5. customThe aqueous layer was separated
6. washafter the organic layer was washed with 5 mL of water twice
7. customthe solvent was evaporated