Acetic Acid → 3',5'-Bis-trifluoromethyl-3-methyl-4-nitrobenzophenone

HRID 1640099Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1640099
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[C:9]([CH3:16])[CH:8]=1.C(O)(=[O:28])C>>[F:1][C:2]([F:24])([F:25])[C:3]1[CH:4]=[C:5]([C:6](=[O:28])[C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[C:9]([CH3:16])[CH:8]=2)[CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1

Komponenten

3

Edukt 2

HCID 176Acetic AcidHCID 592295044-(3,5-Bis-trifluoromethyl-benzyl)-2-methylnitrobenzene

Produkt 1

HCID 219403763',5'-Bis-trifluoromethyl-3-methyl-4-nitrobenzophenone

Versuchsvorschrift

Chromic oxide (IV) (0.41 g) was added to a solution of 4-(3,5-bis-trifluoromethyl-benzyl)-2-methylnitrobenzene (0.3 g) in acetic acid (10 ml) and stirred at room temperature for 1 hour. After the reaction, the reaction solution was extracted with ethyl acetate and washed with water, a saturated sodium bicarbonate solution and a saturated salt solution. After drying over anhydrous magnesium sulfate, the solvent was distilled off and the residue was purified by silica gel column chromatography to obtain 3′,5′-bis-trifluoromethyl-3-methyl-4-nitrobenzophenone (0.3 g).

Aufarbeitung

  1. customAfter the reaction
  2. extractionthe reaction solution was extracted with ethyl acetate
  3. washwashed with water
  4. dry with materialAfter drying over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off
  6. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-6b8be1de32eb4e30ae97f252b2148fb4
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08110689B2

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