反应详情

Chromic oxide (IV) (0.41 g) was added to a solution of 4-(3,5-bis-trifluoromethyl-benzyl)-2-methylnitrobenzene (0.3 g) in acetic acid (10 ml) and stirred at room temperature for 1 hour. After the reaction, the reaction solution was extracted with ethyl acetate and washed with water, a saturated sodium bicarbonate solution and a saturated salt solution. After drying over anhydrous magnesium sulfate, the solvent was distilled off and the residue was purified by silica gel column chromatography to obtain 3′,5′-bis-trifluoromethyl-3-methyl-4-nitrobenzophenone (0.3 g).

1. customAfter the reaction
2. extractionthe reaction solution was extracted with ethyl acetate
3. washwashed with water
4. dry with materialAfter drying over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off
6. customthe residue was purified by silica gel column chromatography