HCID 58902396, compound → HCID 58902217, compound

HRID 1640153Notes

Reaction equation

HRID 1640153 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:17]C(=O)OC(C)(C)C)[CH:8]=[C:9]([CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>Cl.CCOCC>[C:1]([C:5]1[CH:6]=[C:7]([CH:8]=[C:9]([CH2:11][N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:10]=1)[NH2:17])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 58902396HCID 58902396, compound

Product 1

HCID 58902217HCID 58902217, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

tert-Butyl [3-tert-butyl-5-(pyrrolidin-1-ylmethyl)phenyl]carbamate (55 mg, 0.00016 mol) was allowed to stir in 1M Hydrochloric acid in Et2O (10 mL) at rt for 5 h. The reaction mixture was concentrated to give 3-tert-butyl-5-(pyrrolidin-1-ylmethyl)aniline (100%) which was used without purification. LCMS ES+233.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-4e5264165fc1442d8320d2f03cb5b86a
Source dataset
uspto-grants-2012_02
Patent number
US08110687B2

Reaction notes

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