反应详情

A mixture of 1-[3-bromo-5-(trifluoromethyl)phenyl]-2,5-dimethyl-1H-pyrrole (510 mg, 1.6 mmol), 1-methylpiperazine (210 μL, 1.9 mmol), Pd2(dba)3 (70 mg, 0.08 mmol), 2′-BINAP (100 mg, 0.2 mmol) and cesium carbonate (730 mg, 2.2 mmol) in toluene (5.1 mL) was subjected to MWI at 150° C. for 10 min. The reaction mixture was diluted with DCM and washed with brine. The residue was purified by column chromatography to give 1-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-5-(trifluoromethyl)phenyl]-4methylpiperazine (172 mg, 32%) as a yellow solid. LCMS: (FA) ES+ 338.3.

1. washwashed with brine
2. customThe residue was purified by column chromatography