HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-{[7-({[3-cyano-5-(trifluoromethyl)phenyl]-amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}pyridine-2-carboxylate → HCID 58902273, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-{[7-({[3-cyano-5-(trifluoromethyl)phenyl]-amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}pyridine-2-carboxylate | HCID 58902379 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58902273 | HCID 58902273 | 116.9% |
Reaction Steps
A solution of give tert-butyl 4-{[7-({[3-cyano-5-(trifluoromethyl)phenyl]-amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}pyridine-2-carboxylate (0.750 g, 1.40 mmol) in 2M HCl in dioxane (15 mL) was allowed to stir at rt overnight and then evaporated to give 4-{[7-({[3-cyano-5-(trifluoromethyl)phenyl]amino}carbonyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}pyridine-2-carboxylic acid (0.788 g), which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08110687B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-6e6032746fc94bbdbf2392b4252619d3 |
| Source note | uspto-grants-2012_02 |