Hydrochloric Acid → 6-(3-Methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylic acid

Participants

Reaction Steps

140 mg (0.37 mmol) ethyl 6-(3-methyl-2,5-dioxo-1′,3′-dihydrospiro[imidazolidin-4,2′-inden]-5′-ylamino)pyrimidine-4-carboxylate, 5 mL ethanol and 1 mL (1.0 mmol) of a 1M NaOH solution were stirred for 2 h at RT. The reaction mixture was combined with 1 mL of a 1M hydrochloric acid solution and the ethanol was eliminated i.vac. The aqueous residue was cooled and the precipitated product was suction filtered, washed with water and dried.

Provenance & Evidence