Hydrochloric Acid → 6-(3-Methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylic acid

HRID 1640231Notes

Reaction equation

HRID 1640231 reaction equation
[CH3:1][N:2]1[C:6]2([CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[C:11]([NH:15][C:16]4[N:21]=[CH:20][N:19]=[C:18]([C:22]([O:24]CC)=[O:23])[CH:17]=4)[CH:12]=3)[CH2:7]2)[C:5](=[O:27])[NH:4][C:3]1=[O:28].[OH-].[Na+].Cl>C(O)C>[CH3:1][N:2]1[C:6]2([CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[C:11]([NH:15][C:16]4[N:21]=[CH:20][N:19]=[C:18]([C:22]([OH:24])=[O:23])[CH:17]=4)[CH:12]=3)[CH2:7]2)[C:5](=[O:27])[NH:4][C:3]1=[O:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58117486Ethyl 6-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylate

Product 1

HCID 581175346-(3-Methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

140 mg (0.37 mmol) ethyl 6-(3-methyl-2,5-dioxo-1′,3′-dihydrospiro[imidazolidin-4,2′-inden]-5′-ylamino)pyrimidine-4-carboxylate, 5 mL ethanol and 1 mL (1.0 mmol) of a 1M NaOH solution were stirred for 2 h at RT. The reaction mixture was combined with 1 mL of a 1M hydrochloric acid solution and the ethanol was eliminated i.vac. The aqueous residue was cooled and the precipitated product was suction filtered, washed with water and dried.

Workup

  1. temperatureThe aqueous residue was cooled
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-385dc5426bc14d8f8c5526e6f0846dc0
Source dataset
uspto-grants-2012_02
Patent number
US08110575B2

Reaction notes

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