反应详情

1.04 g (5.5 mmol) benzyl-(2,2,2-trifluoroethyl)-amine and 5.5 mL (5.5 mmol) of a 1M sodium hydroxide solution were added dropwise to 1.0 g (5.65 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 20 mL dichloromethane while cooling with a bath of ice and ethanol. The mixture was first stirred for 2 h with cooling and then for 1 h at RT. 50 mL of a saturated sodium hydrogen carbonate solution were added and the mixture was stirred for 10 min. The organic phase was separated off, washed with water and 1M hydrochloric acid, dried on sodium sulphate, filtered and evaporated down i.vac.

1. temperaturewith cooling
2. waitfor 1 h at RT
3. stirringthe mixture was stirred for 10 min
4. customThe organic phase was separated off
5. washwashed with water and 1M hydrochloric acid
6. customdried on sodium sulphate
7. filtrationfiltered
8. customevaporated down i.vac