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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1640243Generated: October 30, 2026

Hydrochloric Acid → HCID 66722373, compound

https://huagongshe.com/reaction/1640243

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-Fluoronicotinic acidHCID 96089—
Reactant5-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-oneHCID 59166722—
SolventIsopropanolHCID 3776—
ProductHCID 66722373HCID 66722373—

Reaction Steps

0.13 g (0.92 mmol) of 2-fluoropyridine-3-carboxylic acid and 20 μL (0.08 mmol) of a 4M aqueous HCl solution were added to 0.20 g (0.78 mmol) 5-amino-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one in 5.0 mL of 2-propanol. The reaction mixture was refluxed for 2 h, then cooled to RT and the resulting solid was filtered off and dried.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08110575B2
Source datasetuspto-grants-2012_02
ORD IDord-e503d192fa2042f29ad459e56cadc29a
Source noteuspto-grants-2012_02