Hydrochloric Acid → HCID 66722373, compound

HRID 1640243Notes

Reaction equation

HRID 1640243 reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl.[NH2:12][C:13]1[CH:14]=[C:15]2[C:28](=[CH:29][CH:30]=1)[CH2:27][C:17]1([C:25]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:19][C:18]1=[O:26])[CH2:16]2>CC(O)C>[O:26]=[C:18]1[NH:19][C:20]2=[N:21][CH:22]=[CH:23][CH:24]=[C:25]2[C:17]21[CH2:16][C:15]1[C:28](=[CH:29][CH:30]=[C:13]([NH:12][C:6]3[CH:5]=[CH:4][N:3]=[CH:2][C:7]=3[C:8]([OH:10])=[O:9])[CH:14]=1)[CH2:27]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 960892-Fluoronicotinic acidHCID 591667225-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Product 1

HCID 66722373HCID 66722373, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.13 g (0.92 mmol) of 2-fluoropyridine-3-carboxylic acid and 20 μL (0.08 mmol) of a 4M aqueous HCl solution were added to 0.20 g (0.78 mmol) 5-amino-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one in 5.0 mL of 2-propanol. The reaction mixture was refluxed for 2 h, then cooled to RT and the resulting solid was filtered off and dried.

Workup

  1. temperatureThe reaction mixture was refluxed for 2 h
  2. filtrationthe resulting solid was filtered off
  3. customdried

Sources & evidence

ORD record
ord-e503d192fa2042f29ad459e56cadc29a
Source dataset
uspto-grants-2012_02
Patent number
US08110575B2

Reaction notes

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