Hydrochloric Acid → 4,4-Dimethyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

Participants

Reaction Steps

6.0 g (36 mmol) methylene-(2-methyl-2-thiophene-3-yl-propyl)-amine, 11 mL (45 mmol) 4M HCl and 12 mL (0.14 mol) conc. HCl were stirred at RT over the weekend. The reaction mixture was made alkaline with a 4M sodium hydroxide solution. The precipitate formed was suction filtered, washed with water and dried. The substance was purified on Alox. The product-containing fractions were combined and concentrated to dryness by rotary evaporation.

Provenance & Evidence