反应详情

1.3 g (20 mmol) sodium cyanoborohydride were added to 0.75 g (4.7 mmol) 2-propyl-1H-indole in 10 mL conc. acetic acid and the mixture was stirred for 5 h at RT. The reaction mixture was evaporated down. The residue was mixed with 20 mL of a 4N HCl solution and stirred for 1 h at RT. Then 45 mL of a 4N sodium hydroxide solution was slowly added while cooling with ice and the mixture was extracted with ethyl acetate. The organic phase was dried on sodium sulphate and evaporated down.

1. customThe reaction mixture was evaporated down
2. additionThe residue was mixed with 20 mL of a 4N HCl solution
3. stirringstirred for 1 h at RT
4. additionThen 45 mL of a 4N sodium hydroxide solution was slowly added
5. temperaturewhile cooling with ice
6. extractionthe mixture was extracted with ethyl acetate
7. customThe organic phase was dried on sodium sulphate
8. customevaporated down