反应详情

50 mg (0.12 mmol) 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylic acid hydrochloride, 16 μL (0.12 mmol) 2-methylindoline, 0.10 mL (0.72 mmol) TEA and 45 mg (0.14 mmol) TBTU in 1.8 mL DMF were stirred overnight at RT. The purification was carried out by preparative HPLC-MS. The product-containing fractions were combined and lyophilised.

1. customThe purification