Diisopropylethylamine → HCID 49801981, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	6-(2'-Oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl-amino)pyrimidine-4-carboxylic acid-hydrochloride	HCID 66722185	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 49801981	HCID 49801981	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

1.2 equivalents (12 μmol) of the amine derivative, 3.4 equivalents DIPEA (34 μmol) and 1.2 equivalents (12 μmol) HATU were added to 4.10 mg (10 μmol) 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylic acid hydrochloride in 0.32 mL DMF and the mixture was shaken overnight at 80° C. The reaction mixture was evaporated down in the vacuum centrifuge at 60° C. The following compounds were able to be synthesised analogously to this working method:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08110575B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-43443ad50038466eaddfd5c06ce54825
Source note	uspto-grants-2012_02