Diisopropylethylamine → HCID 49801981, compound
Reaction equation
CC[N:3]([CH:7]([CH3:9])C)[CH:4]([CH3:6])C.CN(C(ON1N=[N:25][C:20]2C=C[CH:23]=[N:24][C:19]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.Cl.[O:35]=[C:36]1[NH:44][C:39]2=[N:40][CH:41]=[CH:42][CH:43]=[C:38]2[C:37]21[CH2:52][C:51]1[C:46](=[CH:47][CH:48]=[C:49]([NH:53][C:54]3[N:59]=[CH:58][N:57]=[C:56]([C:60](O)=[O:61])[CH:55]=3)[CH:50]=1)[CH2:45]2>CN(C=O)C>[NH:24]1[C:19]2[CH2:9][CH2:7][N:3]([C:60]([C:56]3[N:57]=[CH:58][N:59]=[C:54]([NH:53][C:49]4[CH:50]=[C:51]5[C:46](=[CH:47][CH:48]=4)[CH2:45][C:37]4([C:38]6[C:39](=[N:40][CH:41]=[CH:42][CH:43]=6)[NH:44][C:36]4=[O:35])[CH2:52]5)[CH:55]=3)=[O:61])[CH2:4][CH2:6][C:20]=2[N:25]=[CH:23]1Participants
5
Reactant 3
HCID 81531Diisopropylethylamine
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 667221856-(2'-Oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl-amino)pyrimidine-4-carboxylic acid-hydrochlorideProduct 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
1.2 equivalents (12 μmol) of the amine derivative, 3.4 equivalents DIPEA (34 μmol) and 1.2 equivalents (12 μmol) HATU were added to 4.10 mg (10 μmol) 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylic acid hydrochloride in 0.32 mL DMF and the mixture was shaken overnight at 80° C. The reaction mixture was evaporated down in the vacuum centrifuge at 60° C. The following compounds were able to be synthesised analogously to this working method:
Workup
- customThe reaction mixture was evaporated down in the vacuum centrifuge at 60° C
- customto be synthesised analogously to this working method
Sources & evidence
- ORD record
- ord-43443ad50038466eaddfd5c06ce54825
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08110575B2
Reaction notes
Loading…