3-Phenylprop-2-enenitrile → HCID 86613126, compound

HRID 1640437Notes

Reaction equation

HRID 1640437 reaction equation
[C:1](#[N:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH2:17])[CH:13]=1.[O:18]1[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]1>>[O:18]1[CH2:23][CH2:22][CH:21]([NH:24][C:3]2[CH:2]=[C:1]([NH:17][C:14]3[CH:13]=[C:12]([CH3:11])[NH:16][N:15]=3)[N:10]=[C:1]([CH:2]=[CH:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:10]=2)[CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 746673-Phenylprop-2-enenitrileHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 4192234-Aminotetrahydropyran

Product 1

HCID 86613126HCID 86613126, compound

Procedure

Example 99 was synthesized via Scheme 6 according to the general scheme provided above with the appropriate starting materials cinnamonitrile, 5-methyl-1H-pyrazole-3-amine, and tetrahydro-2H-pyran-4-amine. Structure of the target was confirmed by 1H-NMR. The 1H-NMR is attached.

Workup

  1. customExample 99 was synthesized via Scheme 6 according to the general scheme
  2. customprovided above with the

Sources & evidence

ORD record
ord-da6578ca0c12410c966feab35e034bdb
Source dataset
uspto-grants-2012_02
Patent number
US08114870B2

Reaction notes

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