反应详情

To a solution of 6-methoxy-[1,5]naphthyridin-4-ylamine (553 mg, 3.16 mmol) in THF (45 mL) was added potassium tert-butoxide (390 mg, 1.1 eq.) at 0° C. The resulting brown suspension was stirred at rt for 1.5 h and then added dropwise to a solution of ethyl chloroacetate (387 mg, 1 eq.) in THF (30 mL) at −5° C. The mixture was allowed to warm to rt and was further stirred for 3 h. Water was added and the mixture was concentrated under reduced pressure. The resulting precipitate was filtered and further dried at HV to afford the title intermediate as a beige solid (357 mg, 45% yield).

1. temperatureto warm to rt
2. stirringwas further stirred for 3 h
3. concentrationthe mixture was concentrated under reduced pressure
4. filtrationThe resulting precipitate was filtered
5. customfurther dried at HV