反应详情

A suspension of 8-bromomethyl-7-fluoro-2-methoxy-quinoline (32.03 g, 118.59 mmol) in acetone (460 mL) and water (585 mL) was treated with NaHCO3 (16.32 g, 194.28 mmol). The mixture was heated at reflux for 6 h. The volatiles were removed under reduced pressure and the aq. phase was extracted with EA (2×250 mL). The combined org. layers were washed with brine, dried over MgSO4 and concentrated to afford the title alcohol as a yellow oil (24 g, 97% yield).

1. temperatureThe mixture was heated
2. temperatureat reflux for 6 h
3. customThe volatiles were removed under reduced pressure
4. extractionthe aq. phase was extracted with EA (2×250 mL)
5. washlayers were washed with brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated