Hydrochloric Acid → 5-Methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylic acid

HRID 1640686Notes

Reaction equation

HRID 1640686 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:6](=[O:14])[C:7]([C:10]([O:12]C)=[O:11])=[N:8][CH:9]=1.Cl>CCO>[CH3:3][C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:22])[F:23])[CH:16]=2)[C:6](=[O:14])[C:7]([C:10]([OH:12])=[O:11])=[N:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58432791AZ-32S-methyl-ester

Product 1

HCID 667387495-Methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

NaOH (1M, 6 ml) was added to methyl 5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate (0.60 g, 1.92 mmol) dissolved in EtOH (12 ml) and the to mixture was stirred for 15 minutes. The aqueous phase was neutralized by addition of HCl (1M, 7 ml) to pH 6 to 7 and extracted with ethyl acetate (3×15 ml). The organic phase was dried (MgSO4), filtered and evaporated. No further purification was performed.

Workup

  1. extractionextracted with ethyl acetate (3×15 ml)
  2. dry with materialThe organic phase was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated
  5. customNo further purification

Sources & evidence

ORD record
ord-2e3130e4a72345968daa58ed5b9dece7
Source dataset
uspto-grants-2012_02
Patent number
US08114881B2

Reaction notes

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