Hydrochloric Acid → 1-(6-Fluoro-4-iodo-pyridin-3-yl)-ethanol

Participants

Reaction Steps

Add 1 N HCl (5 mL) to a solution of 2-fluoro-4-iodo-5-(1-methoxymethoxy-ethyl)-pyridine (1 g, 3.2 mmol) in methanol (10 mL). Stir the mixture overnight. Dilute the reaction mixture with sodium carbonate (2 N). Extract the product into chloroform. Dry the organic phase over sodium sulfate. Concentrate the solution in vacuo. Purify the crude by column chromatography (10% methanol in DCM) to afford the title compound as a white solid (0.75 g, 87%). MS (ES) m/z 268 [M+1]+.

Provenance & Evidence