反应详情

Add 1 N HCl (5 mL) to a solution of 2-fluoro-4-iodo-5-(1-methoxymethoxy-ethyl)-pyridine (1 g, 3.2 mmol) in methanol (10 mL). Stir the mixture overnight. Dilute the reaction mixture with sodium carbonate (2 N). Extract the product into chloroform. Dry the organic phase over sodium sulfate. Concentrate the solution in vacuo. Purify the crude by column chromatography (10% methanol in DCM) to afford the title compound as a white solid (0.75 g, 87%). MS (ES) m/z 268 [M+1]+.

1. extractionExtract the product into chloroform
2. dry with materialDry the organic phase over sodium sulfate
3. concentrationConcentrate the solution in vacuo
4. customPurify the crude by column chromatography (10% methanol in DCM)