Hydrochloric Acid → HCID 66739140, compound

HRID 1641031Notes

Reaction equation

HRID 1641031 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13](=[O:33])[C:14]([NH:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][NH:25]C(=O)OC(C)(C)C)[CH2:19][CH2:18]2)=[O:15])=[CH:5]1)([CH3:3])[CH3:2].[ClH:34].CO>>[ClH:34].[NH2:25][CH2:24][CH2:23][N:20]1[CH2:21][CH2:22][CH:17]([NH:16][C:14](=[O:15])[C:13]([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[N:4]([CH:1]([CH3:2])[CH3:3])[CH:5]=2)=[O:33])[CH2:18][CH2:19]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 59438566HCID 59438566, compound

Product 1

HCID 66739140HCID 66739140, compoundYield 100%

Procedure

The title compound was prepared according to general procedure D described in Scheme 2. tert-Butyl 2-(4-(2-(1-isopropyl-1H-indol-3-yl)-2-oxoacetamido)piperidin-1-yl)ethylcarbamate (132 mg, 0.29 mmol) was treated with 3 N HCl in MeOH (2 mL, 1.2 mmol) and stirred at RT for 30 min. The reaction mixture was concentrated under reduced pressure to afford the title compound as a pink solid (106 mg, 100%), which was used without further purification in the sulfonamide formation.

Workup

  1. customThe title compound was prepared
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9c7b13766ac74a499d5f1b6928312a24
Source dataset
uspto-grants-2012_02
Patent number
US08114894B2

Reaction notes

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