Piperidine → 3-Fluoro-5-morpholin-4-yl-N-{4-[(2-piperidin-1-ylpyrimidin-4-yl)oxy]-1-naphthyl}benzamide

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Reaction Steps

Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and piperidine according to conditions described in general procedure C. Mp: 190-191° C.; 1H NMR (400 MHz, CDCl3) δ 1.52-1.63(m, 6 H), 3.27-3.63(m, 4 H), 3.72(m, 4H), 3.87(m, 4 H), 5.81-5.83(m, 1 H), 5.92-5.94(m, 1 H), 6.78(d, J=10.0 Hz, 1 H), 7.08(d, J=6.4 Hz, 1 H), 7.33-7.35(m, 2 H), 7.50-7.61(m, 2 H), 7.89-7.91(m, 1 H), 7.96-8.14(m, 1 H), 8.12-8.17(m, 2 H).

Provenance & Evidence