Piperidine → 3-Fluoro-5-morpholin-4-yl-N-{4-[(2-piperidin-1-ylpyrimidin-4-yl)oxy]-1-naphthyl}benzamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[NH:38]1[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:38]3[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]Participants
3
Procedure
Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and piperidine according to conditions described in general procedure C. Mp: 190-191° C.; 1H NMR (400 MHz, CDCl3) δ 1.52-1.63(m, 6 H), 3.27-3.63(m, 4 H), 3.72(m, 4H), 3.87(m, 4 H), 5.81-5.83(m, 1 H), 5.92-5.94(m, 1 H), 6.78(d, J=10.0 Hz, 1 H), 7.08(d, J=6.4 Hz, 1 H), 7.33-7.35(m, 2 H), 7.50-7.61(m, 2 H), 7.89-7.91(m, 1 H), 7.96-8.14(m, 1 H), 8.12-8.17(m, 2 H).
Sources & evidence
- ORD record
- ord-2635859ed0fb45019ced4924e4e1d3dc
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08114873B2
Reaction notes
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