Pyrrolidine → 3-Fluoro-5-morpholin-4-yl-N-{4-[(2-pyrrolidin-1-ylpyrimidin-4-yl)oxy]-1-naphthyl}benzamide
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[NH:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]참가 물질
3
실험 절차
Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and pyrrolidine according to conditions described in general procedure C. Mp: 205-207° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.81 (s, 4 H), 3.06 s, 2 H), 3.27 (s, 4 H), 3.41 (s, 2 H), 3.77 (s, 4 H), 6.27-6.19 (m, 1 H), 7.03-7.06 (m, 1 H), 7.27 (d, J=9.1 Hz, 1H), 7.42-7.46 (m, 1H), 7.51 (s, 1 H), 7.57-7.639 (m, 3 H), 7.86 (d, J=8.4 Hz, 1 H), 8.00 (d, J=8.3 Hz, 1 H), 8.23-8.25 (m, 1 H), 10.47 (s, 1 H).
출처 및 근거
- ORD 기록
- ord-0c9ae119ce7345968022af2b04994744
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08114873B2
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