Tetrahydrofurfurylamine → HCID 59553308, compound
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[O:38]1[CH2:42][CH2:41][CH2:40][CH:39]1[CH2:43][NH2:44]>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH:44][CH2:43][CH:39]3[CH2:40][CH2:41][CH2:42][O:38]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]Participants
3
Procedure
Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and C-(tetrahydro-furan-2-yl)-methylamine according to conditions described in general procedure C. Mp: 103-105° C.; 1H NMR (400 MHz, CDCl3) δ 1.55-1.80 (m, 4 H), 3.21 (t, J=4.4 Hz, 4 H), 3.45-3.89 (m, 5 H), 3.83 (t, J=4.8 Hz, 4 H), 5.42 (s, 1 H), 6.06 (s, 1 H), 6.75 (d, J=11.7 Hz, 1H), 7.07 (d, J=8.0 Hz, 1 H), 7.22 (d, J=8.4 Hz, 1H), 7.30 (s, 1 H), 7.42-7.52 (m, 2 H), 7.77-7.94 (m, 3 H), 8.11 (s, 1 H), 8.40 (s, 1 H).
Sources & evidence
- ORD record
- ord-3e1cccbc57fa49eda9e2d2263db14cc7
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08114873B2
Reaction notes
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