Tetrahydrofurfurylamine → HCID 59553308, compound

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Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and C-(tetrahydro-furan-2-yl)-methylamine according to conditions described in general procedure C. Mp: 103-105° C.; 1H NMR (400 MHz, CDCl3) δ 1.55-1.80 (m, 4 H), 3.21 (t, J=4.4 Hz, 4 H), 3.45-3.89 (m, 5 H), 3.83 (t, J=4.8 Hz, 4 H), 5.42 (s, 1 H), 6.06 (s, 1 H), 6.75 (d, J=11.7 Hz, 1H), 7.07 (d, J=8.0 Hz, 1 H), 7.22 (d, J=8.4 Hz, 1H), 7.30 (s, 1 H), 7.42-7.52 (m, 2 H), 7.77-7.94 (m, 3 H), 8.11 (s, 1 H), 8.40 (s, 1 H).

Provenance & Evidence