4-Methylpiperidine → HCID 59553372, compound

HRID 1641193Notes

Reaction equation

HRID 1641193 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH3:38][CH:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:42]3[CH2:43][CH2:44][CH:39]([CH3:38])[CH2:40][CH2:41]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 693814-MethylpiperidineHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553372HCID 59553372, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 4-methylpiperidine according to conditions described in general procedure C. Mp: 145-146° C.; 1H NMR (400 MHz, DMSO-d6) δ 0.86 (d, J=6.0 Hz, 3 H), 1.50-1.62 (m, 11 H), 3.30 (m, 8H), 6.19-6.21 (m, 1 H), 6.99 (d, J=11.0 Hz, 1 H), 7.19 (d, J=9.0 Hz, 1 H), 7.41-7.43 (m, 1 H), 7.49 (s, 1 H), 7.57-7.62 (m, 3 H), 7.85 (d, J=8.2 Hz, 1H), 7.99 (d, J=8.5 Hz, 1 H), 8.25-8.27 (m, 1 H), 10.46 (s, 1 H).

Sources & evidence

ORD record
ord-5f063c9be61545cf917db30e175bae1d
Source dataset
uspto-grants-2012_02
Patent number
US08114873B2

Reaction notes

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