HRID1641194

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75645

Cyclobutanamine

C4H9N

结构：CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCCCC4)c3)c3ccccc23)n1

HCID66737969

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(Oc2ccnc(NC3CCC3)n2)c2ccccc12)c1cc(F)cc(N2CCCCC2)c1

HCID59553208

未命名化合物

PROCEDURE

实验过程

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and cyclobutylamine according to conditions described in general procedure C. Mp: 112-114° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.58-1.61 (m, 7 H), 1.80 (bs, 2 H), 2.10 (s, 1 H), 3.27-3.28 (m, 5 H), 6.32 (s, 1 H), 6.98 (d, 1 H), 7.15 (d, 1 H), 7.36-7.54 (m, 3 H), 7.57-7.62 (m, 3 H), 7.80 (d, 1 H), 7.95 (d, 1 H), 8.20 (s, 1 H), 10.41 (s, 1 H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-31bfe49094854e92a8e5459f21353604
来源数据集: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08114873B2
来源说明: uspto-grants-2012_02

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH:38]1([NH2:42])[CH2:41][CH2:40][CH2:39]1>>[CH:38]1([NH:42][C:21]2[N:20]=[C:19]([O:18][C:11]3[C:12]4[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=4)[C:8]([NH:7][C:5](=[O:6])[C:4]4[CH:29]=[C:30]([N:32]5[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]5)[CH:31]=[C:2]([F:1])[CH:3]=4)=[CH:9][CH:10]=3)[CH:24]=[CH:23][N:22]=2)[CH2:41][CH2:40][CH2:39]1