HRID1641213

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

结构：CS(=O)(=O)c1nccc(Oc2ccc(NC(=O)c3cc(F)cc(N4CCCCC4)c3)c3ccccc23)n1

HCID66737969

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(Oc2ccnc(N3CCCCC3)n2)c2ccccc12)c1cc(F)cc(N2CCCCC2)c1

HCID59553172

未命名化合物

PROCEDURE

实验过程

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and piperidine according to conditions described in general procedure C. 1H NMR (400 MHz, DMSO-d6) δ 1.34-1.58 (m, 12 H), 3.21-3.35 (m, 8 H), 6.18 (d, J=5.5 Hz, 1 H), 6.95 (d, J=12.4 Hz, 1 H), 7.15 (d, J=10.6 Hz, 1 H), 7.40 (d, J=8.0 Hz, 1 H), 7.46 (s, 1 H), 7.55-7.60 (m, 3 H), 7.81-7.83 (m, 1 H), 7.97 (d, J=7.3 Hz, 1 H), 8.24 (d, J=5.5 Hz, 1 H), 10.43 (s, 1 H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f8b6c15b99a34f068a23fbf75c5f0693
来源数据集: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08114873B2
来源说明: uspto-grants-2012_02

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[NH:38]1[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:38]3[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]