反应详情

温度

75 °C

A mixture of 3-fluoro-5-hexyloxybenzonitrile (1.0 g, 4.56 mmol), ethanol (12 ml), water (12 ml), and aq. NaOH (50%, 12 ml) is heated at 75° C. for 18 hours. The mixture is then cooled in an ice bath and acidified with concentrated HCl to pH 1. The mixture is extracted with ethyl acetate and the organic layer washed with brine, dried over Na2SO4, and concentrated to afford 3-fluoro-5-cyclohexyloxybenzoic acid as a yellow solid. MS: 239.11(M+1).

1. temperatureThe mixture is then cooled in an ice bath
2. extractionThe mixture is extracted with ethyl acetate
3. washthe organic layer washed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated