Hydrochloric Acid → HCID 66737976, compound

HRID 1641279Notes

Reaction equation

HRID 1641279 reaction equation
C(OC(=O)[NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH2:19][CH2:20][Cl:21])=[CH:10][CH:9]=1)(C)(C)C.Cl.C(OCC)C>O1CCOCC1>[ClH:21].[Cl:21][CH2:20][CH2:19][O:18][C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([NH2:7])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 10892606HCID 10892606, compound

Product 1

HCID 66737976HCID 66737976, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of [4-(2-chloro-ethoxy)-naphthalen-1-yl]-carbamic acid tert-butyl ester (1.387 g, 4.3 mmol) in anhydrous dioxane (10 ml) at room temperature is added a solution of 4M HCl in dioxane (15 ml). After 18 hours diethyl ether (150 ml) is added and 4-(2-chloroethoxy)-naphthalen-1-ylamine hydrochloride salt filtered off as a pink solid (1.081 g).

Workup

  1. filtration4-(2-chloroethoxy)-naphthalen-1-ylamine hydrochloride salt filtered off as a pink solid (1.081 g)

Sources & evidence

ORD record
ord-76fb474f23ab474e87b18b5052d71f87
Source dataset
uspto-grants-2012_02
Patent number
US08114873B2

Reaction notes

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