1-Acetylpiperazine → HCID 59553079, compound

HRID 1641285Notes

Reaction equation

Cl[CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:15][C:16](=[O:30])[C:17]2[CH:22]=[C:21]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:20]=[C:19]([F:29])[CH:18]=2)=[CH:7][CH:6]=1.[C:31]([N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)(=[O:33])[CH3:32]>>[C:31]([N:34]1[CH2:39][CH2:38][N:37]([CH2:2][CH2:3][O:4][C:5]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]([NH:15][C:16](=[O:30])[C:17]3[CH:22]=[C:21]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[CH:20]=[C:19]([F:29])[CH:18]=3)=[CH:7][CH:6]=2)[CH2:36][CH2:35]1)(=[O:33])[CH3:32]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 59553352HCID 59553352, compound

Product 1

HCID 59553079HCID 59553079, compound

Procedure

Compound is prepared from N-[4-(2-chloroethoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamide and 4-acetylpiperizine according to conditions described in general procedure N. 1H NMR 300 MHz (CDCl3) 8.3(dd, 1H, J=1.8 and 8.7 Hz), 7.9(s, 1H), 7.84(d, 1H, J=7.5 Hz), 7.74(d, 1H, J=8.7 Hz), 7.54(m, 2H), 7.31(s, 1H), 6.99(d, 1H, J=7.5 Hz), 6.84(d, 1H, J=8.1 Hz), 6.76(d, 1H, J=11.7 Hz), 4.32(t, 2H, J=5.7 Hz), 3.66(t, 2H, J=5.4), 3.5(t, 2H, J=5.4 Hz), 3.28(m, 4H), 3.0 (t, 2H, J=5.7 Hz), 2.65(m, 4H), 2.05(s, 3H), 1.62-1.8(m, 6H).

Sources & evidence

ORD record: ord-154a83b74ade4f5f9fb3f0867a5eeb2f
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114873B2

Reaction notes

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