反应详情

Under argon, 60 mg (0.22 mmol) of 4-(2-fluoro-4-nitrophenoxy)-1H-indazole (from example XXV) are initially charged in 5 ml of ethanol/tetrahydrofuran (1:1), 9.97 mg (0.04 mmol) of platinum(IV) oxide are added and the mixture is hydrogenated under atmospheric pressure for 2 hours. The suspension is filtered off through CELITE (diatomaceous earth), the filtercake is washed with ethanol and the filtrate is concentrated under reduced pressure.

1. filtrationThe suspension is filtered off through CELITE (diatomaceous earth)
2. washthe filtercake is washed with ethanol
3. concentrationthe filtrate is concentrated under reduced pressure