HCID 178509762, compound → HCID 178509763, compound

HRID 1641311Notes

Reaction equation

HRID 1641311 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:32]=[CH:33][CH:34]=1)[CH2:6][N:7]1[CH2:31][CH2:30][C:10]2([N:14]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=3)[C:13](=[O:22])[N:12]=[C:11]2[NH:23][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:9][CH2:8]1)#[N:2]>CCO>[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([CH:32]=[CH:33][CH:34]=1)[CH2:6][N:7]1[CH2:31][CH2:30][C:10]2([N:14]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=3)[C:13](=[O:22])[N:12]=[C:11]2[NH:23][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:9][CH2:8]1

Participants

3

Reactant 1

HCID 178509762HCID 178509762, compound

Product 1

HCID 178509763HCID 178509763, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 50 mL EtOH suspension of 0.470 g (1.02 mmol) 8-[3-cyanobenzyl]-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one (Example (7-12)) and a small amount of Raney Nickel (in water) was first evacuated and flushed with N2 3 times then put under a H2 balloon and allowed to stir overnight. The catalyst was filtered and the filtrate concentrated in vacuo to pure product.

Workup

  1. customa small amount of Raney Nickel (in water) was first evacuated
  2. customflushed with N2 3 times
  3. filtrationThe catalyst was filtered
  4. concentrationthe filtrate concentrated in vacuo to pure product

Sources & evidence

ORD record
ord-8473bf86f0344f159e9ef2f863e3d3ec
Source dataset
uspto-grants-2012_02
Patent number
US08114887B2

Reaction notes

Loading…