HCID 178509762, compound → HCID 178509763, compound

Participants

Reaction Steps

A 50 mL EtOH suspension of 0.470 g (1.02 mmol) 8-[3-cyanobenzyl]-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one (Example (7-12)) and a small amount of Raney Nickel (in water) was first evacuated and flushed with N2 3 times then put under a H2 balloon and allowed to stir overnight. The catalyst was filtered and the filtrate concentrated in vacuo to pure product.

Provenance & Evidence