HRID1641330

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID81531

Diisopropylethylamine

C8H19N

HCID97478

1-(4-Chlorophenyl)piperazine

C10H13ClN2

结构：CC(C)[C@@H](Nc1nc(Cl)nc2c1SCC2)C(N)=O

HCID59708380

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@@H](Nc1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1SCC2)C(N)=O

HCID59708455

未命名化合物

收率 88.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度: 160 °C

PROCEDURE

实验过程

400 mg (R)-2-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-3-methyl-butyramide, 750 mg 1-(4-chloro-phenyl)-piperazine and 1.2 ml diisopropylethylamine are placed in 9 ml dioxane, then heated in the microwave for 1 hour and 45 minutes at 160° C. Then water is added. The precipitate formed is suction filtered and dried. 550 mg of the product are obtained as a powder. Analytical HPLC (method B): RT=3.03 min.

WORKUP

后处理

customThe precipitate formed
filtrationfiltered
customdried