Hydrochloric Acid → (R)-Chroman-4-ylamine hydrochloride

Participants

Reaction Steps

A solution of the above N-[(4R)4-chromanyl]-2-methoxyacetamide (2.2 g, 0.0325 mol) in ethanol (100 ml) and concentrated hydrochloric acid (30 ml) was heated at reflux for 12 hours, then evaporated. A small amount of ethyl acetate was added to the residue and the solid filtered off to give (4R)4-aminochromane hydrochloride (2.3 g), m.p. 261-263° C., chemical purity>95%.

Provenance & Evidence