Hydrochloric Acid → (R)-Chroman-4-ylamine hydrochloride

HRID 1641376Notes

Reaction equation

HRID 1641376 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@H:4]([NH:11]C(=O)COC)[CH2:3][CH2:2]1.[ClH:17]>C(O)C>[ClH:17].[NH2:11][C@H:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[O:1][CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24895518HCID 24895518, compound

Product 1

HCID 53249223(R)-Chroman-4-ylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the above N-[(4R)4-chromanyl]-2-methoxyacetamide (2.2 g, 0.0325 mol) in ethanol (100 ml) and concentrated hydrochloric acid (30 ml) was heated at reflux for 12 hours, then evaporated. A small amount of ethyl acetate was added to the residue and the solid filtered off to give (4R)4-aminochromane hydrochloride (2.3 g), m.p. 261-263° C., chemical purity>95%.

Workup

  1. temperatureat reflux for 12 hours
  2. customevaporated
  3. additionA small amount of ethyl acetate was added to the residue
  4. filtrationthe solid filtered off

Sources & evidence

ORD record
ord-c6d60625036e4f95912a3301e8890e30
Source dataset
uspto-grants-2012_02
Patent number
US08114991B2

Reaction notes

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